Testosterone Restoration Therapy

Testosterone restoration therapy returns your testosterone levels to balance without testosterone injections or supplements. At New England Low-T Center, with offices in Fairfield and Southbury, Connecticut, the team of men’s health specialists and hormone optimization experts proudly offers testosterone restoration therapy, an advanced treatment that can help you restore your testosterone levels naturally. Call the nearest office to request a testosterone restoration therapy consultation, or book one online today.

What is testosterone restoration therapy?

Testosterone restoration therapy is a cutting-edge treatment designed to increase testosterone production naturally. Restoring one's natural testosterone levels without Testosterone Therapy is not for everyone. But for those who qualify for this treatment, it is a way to increase your brain's signal to the testes, telling them to increase testosterone production naturally.

How does testosterone restoration therapy work?

Testosterone restoration therapy uses a class of drugs called selective estrogen receptor modulators (SERMs) to block estrogen from binding to estrogen receptors in the brain. 

Selective Estrogen Receptor Modulators (SERMs) act as estrogen antagonists—they block estrogen from binding to the estrogen receptor in the brain, at the hypothalamus, and the pituitary gland.

So when the brain thinks that it’s not getting enough estrogen, it stimulates the production of the hormones luteinizing hormone (LH) and Follicle Stimulating Hormone (FSH), which increases the testes’ production of testosterone and sperm, respectively. This stimulates your body to produce more of its own natural testosterone.

What type of medication does testosterone restoration therapy use?

At New England Low-T Center, the team prescribes a drug called enclomiphene citrate for testosterone restoration therapy. Enclomiphene is the purified isomer of Clomid (Clomiphene Citrate), which has been FDA-approved since 1967 for fertility in women and has been commonly used off-label in men. Many research studies suggest Clomid is safe and effective with few side effects when used as long-term treatment of hypogonadism (low testosterone) and is an “effective and safe alternative to testosterone supplementation in [young] men wishing to preserve their fertility.”

However, Clomid is actually made up of a mixture of two isomers: 38% zuclomiphene and 62% enclomiphene. Zuclomiphene is an estrogen receptor agonist (increases estrogen) that stays in your system for a long time and accumulates much more over time than enclomiphene.

Clomid is believed to cause some minor side effects such as mood swings, depressed mood, irritability, anxiety, gynecomastia, libido issues, and ocular vessel swelling that can develop in a small percentage of patients over time.

"The literature has suggested that most of the beneficial effects of clomiphene are due to the trans-isomer enclomiphene. Zuclomiphene contributes little to the intended outcomes.“

How long does it take for testosterone restoration therapy to work?

The time it takes for testosterone restoration therapy to work depends on your individual hormone levels and whether you take the medication as prescribed. Most people experience an improvement in their symptoms within 3-4 months,* but it may take longer. Be patient, follow your provider’s instructions, and attend each checkup as scheduled.

Is testosterone restoration therapy safe?

The adverse effects of Enclomiphene have been extensively studied during phase II and phase III clinical trials. The drug is generally well tolerated, with side effects occurring relatively rarely.

• Headache(was observed in 3.3% of patients)
• Common Cold(was observed in 1.7% of patients)
• Nausea(was observed in 2.1% of patients) 
• Hot flush(was observed in 1.7% of patients)
• Diarrhea(was observed in 1.9% of patients)
• Joint pain(was observed in 1.2% of patients)
• Dizziness(was observed in 1% of patients)

These symptoms should improve within a week or two, but if they continue or worsen, contact your provider right away. The team can adjust your medication levels and help you feel better.

Call us at 877-349-5698 to learn more about testosterone restoration therapy, or use the online booking feature today.

*Individual results may vary.

• Earl JA, Kim ED. Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism. Expert Rev Endocrinol Metab. 2019;14(3):157-65.